Drugs & infusions
J2405 — Ondansetron hydrochloride, per 1 mg
Ondansetron (brand name Zofran) is an anti-nausea injection commonly used to treat nausea and vomiting from chemotherapy, surgery, or illness.
- Typical setting: Hospital, outpatient clinic
- National avg charge (illustrative): $10–$40 per dose (drug cost)
- Most-disputed reason: Quantity inflation: 4 mg dose = 4 units of J2405; billing 40 units for a 4 mg dose is a 10x overbill — one of the most common J-code fraud patterns
What it means
What J2405 actually means
Ondansetron (brand name Zofran) is an anti-nausea injection commonly used to treat nausea and vomiting from chemotherapy, surgery, or illness. A typical IV dose is 4 mg; since the code is per 1 mg, a 4 mg dose = 4 units on the bill.
Common errors with this code
What goes wrong on real bills.
Most bills that look correct still contain at least one of these issues. Up to 49% of medical bills contain errors (CFPB).
- Quantity inflation: 4 mg dose = 4 units of J2405; billing 40 units for a 4 mg dose is a 10x overbill — one of the most common J-code fraud patterns
- Billing J2405 for oral Zofran ODT (the injectable code does not apply to oral formulations)
- Charging separately for ondansetron already bundled into a chemotherapy pre-medication protocol
If you see J2405 on your bill
Three steps before paying.
1. Get the itemized bill. If your statement only shows a summary, request the CPT-level itemized bill before paying. Generate the request language →
2. Cross-check against the EOB. Compare what your insurer's Explanation of Benefits says you owe versus what the hospital is asking. They disagree more often than people think. Read the bill-vs-EOB guide →
3. Run a free Bill Scan. Upload the bill (and EOB if you have it) and BillBusted will flag the most likely issues with this specific code in your specific state. Run free scan →
Related codes
Other codes in this category.
People who land on J2405 often also see these adjacent codes on the same bill.
Related BillBusted guides
Plain-English reads if you see J2405 on a bill.
J2405 FAQ
Plain-English answers.
What does J2405 usually cost?
$10–$40 per dose (drug cost). Costs vary by region, payer contract, and whether the service was performed in a hospital outpatient department (which adds a facility fee) versus a free-standing clinic.
What's the most common billing error on J2405?
Quantity inflation: 4 mg dose = 4 units of J2405; billing 40 units for a 4 mg dose is a 10x overbill — one of the most common J-code fraud patterns
What should I do if I see J2405 on my bill?
Request the itemized bill and the matching EOB from your insurer. Compare the units/quantity billed against what you actually received. Run a free BillBusted scan to flag the most likely errors specific to J2405 before paying.
Don't pay J2405 blindly.
The free scan tells you in under 60 seconds whether this charge looks reasonable for your situation.